Oxaceprol

Chemical compound

D11AX09 (WHO) M01AX24 (WHO)

Identifiers

IUPAC name

(4R)-1-acetyl-4-hydroxy-L-proline

CAS Number

33996-33-7^Y

PubChem CID

65784

ChemSpider

59203

UNII

Q0XV76B96L

KEGG

D07215^Y

ChEMBL

ChEMBL1407356

CompTox Dashboard (EPA)

DTXSID2046410

ECHA InfoCard100.047.058

Chemical and physical dataFormulaC₇H₁₁NO₄Molar mass173.168 g·mol⁻¹3D model (JSmol)

Interactive image

SMILES

CC(=O)N1C[C@@H](C[C@H]1C(=O)O)O

InChI

InChI=1S/C7H11NO4/c1-4(9)8-3-5(10)2-6(8)7(11)12/h5-6,10H,2-3H2,1H3,(H,11,12)/t5-,6+/m1/s1
Key:BAPRUDZDYCKSOQ-RITPCOANSA-N

(verify)

Oxaceprol is an anti-inflammatory drug used in the treatment of osteoarthritis.^[1] It is derived from L-proline, a DNA-encoded amino acid. The active effect of Oxaceprol is to inhibit the adhesion and migration of white blood cells.^[2]

References

^ Herrmann G, Steeger D, Klasser M, Wirbitzky J, Fürst M, Venbrocks R, et al. (2000). "Oxaceprol is a well-tolerated therapy for osteoarthritis with efficacy equivalent to diclofenac". Clinical Rheumatology. 19 (2): 99–104. doi:10.1007/s100670050025. PMID 10791619. S2CID 25654850.
^ Clayton JJ (August 2007). "Nutraceuticals in the management of osteoarthritis". Orthopedics. 30 (8): 624–9, quiz 630-1. doi:10.3928/01477447-20070801-13. PMID 17727018. Retrieved 2013-06-08.

External links

"Oxaceprol". Drug Information Portal. U.S. National Library of Medicine.

Other dermatological preparations (D11)

Anti-seborrheics

Antiandrogens
Antifungals
Antihistamines
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Isotretinoin
Keratolytics
Lithium salts
- Lithium gluconate
- Lithium succinate
Topical corticosteroids (e.g., hydrocortisone)

Skin lightening

Skin darkening

Anti-inflammatories

Oxaceprol
Gamolenic acid
Pimecrolimus
Tacrolimus
Alitretinoin
Topical corticosteroids (e.g., hydrocortisone)

Alopecia treatments

Hair growth inhibitors

Others

v t e Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
pyrazolones / pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone^‡
salicylates	Aspirin (acetylsalicylic acid)^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate
acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bufexamac Bumadizone Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indometacin Indometacin farnesil Isoxepac Ketorolac Lonazolac Mofezolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac^†
oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Pivoxicam Tenoxicam
propionic acid derivatives (profens)	Alminoprofen Benoxaprofen^† Carprofen^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen^# Ibuproxam Indoprofen^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pelubiprofen Piketoprofen Pirprofen Suprofen Tarenflurbil Tepoxalin^‡ Tiaprofenic acid Vedaprofen^‡ Zaltoprofen COX-inhibiting nitric oxide donator: Naproxcinod
n-arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Floctafenine Flufenamic acid Flunixin Flutiazin Glafenine^† Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid
COX-2 inhibitors (coxibs)	Apricoxib Celecoxib (+tramadol) Cimicoxib^‡ Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Mavacoxib^‡ Parecoxib Robenacoxib^‡ Rofecoxib^† Valdecoxib^†
other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase / orgotein Tenidap
NSAID combinations	Ibuprofen/famotidine Ibuprofen/hydrocodone Ibuprofen/oxycodone Ibuprofen/paracetamol Meloxicam/bupivacaine Naproxen/diphenhydramine Naproxen/esomeprazole
Key: underline indicates initially developed first-in-class compound of specific group; ^#WHO-Essential Medicines; ^†withdrawn drugs; ^‡veterinary use.
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