Fentiazac
NSAID analgesic medication
- M02AA14 (WHO)
- 2-[4-(4-chlorophenyl)-2-phenyl-1,3-thiazol-5-yl]acetic acid
- 18046-21-4
N
- 28871
- 26854 N
- 0YHF6E6NLS
- D01975
Y
- ChEMBL589092 N
- DTXSID8023050
- Interactive image
- c1ccc(cc1)c2nc(c(s2)CC(=O)O)c3ccc(cc3)Cl
InChI
- InChI=1S/C17H12ClNO2S/c18-13-8-6-11(7-9-13)16-14(10-15(20)21)22-17(19-16)12-4-2-1-3-5-12/h1-9H,10H2,(H,20,21)N
- Key:JIEKMACRVQTPRC-UHFFFAOYSA-NN
N
Y (what is this?) (verify)Fentiazac is a thiazole-based nonsteroidal anti-inflammatory drug (NSAID) developed for use in joint and muscular pain.[1] Like most other NSAIDs, it acts through inhibition of prostaglandin synthesis, via non-selective inhibition of both COX-1 and COX-2. First described in 1974, it was synthesized using the Hantzsch thiazole synthesis.[2]
Fentiazac was marketed under the trade-name Norvedan (among others), but its market status is currently unknown and assumed to be discontinued.[3]
See also
References
- ^ Lombardino JG (1985). Nonsteroidal antiinflammatory drugs. Vol. 247. New York: Wiley. p. 285. ISBN 978-0-471-89803-0.
- ^ Brown K, Cater DP, Cavalla JF, Green D, Newberry RA, Wilson AB (November 1974). "Nonsteroidal antiinflammatory agents. 1.2,4-Diphenylthiazole-5-acetic acid and related compounds". Journal of Medicinal Chemistry. 17 (11): 1177–1181. doi:10.1021/jm00257a010. PMID 4414839.
- ^ "FENTIAZAC". NCATS Inxight Drugs. National Center for Advancing Translational Sciences (NCATS); U.S. National Institutes of Health. Retrieved 2023-06-08.
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Key: underline indicates initially developed first-in-class compound of specific group; #WHO-Essential Medicines; †withdrawn drugs; ‡veterinary use.
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