| 朊毒體蛋白 |
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| 已知的結構 |
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| PDB | 直系同源搜索: PDBe RCSB |
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| PDBID列表 |
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1E1G、1E1J、1E1P、1E1S、1E1U、1E1W、1FKC、1FO7、1H0L、1HJM、1HJN、1I4M、1OEH、1OEI、1QLX、1QLZ、1QM0、1QM1、1QM2、1QM3、2IV4、2IV5、2IV6、2K1D、2KUN、2LBG、2LEJ、2LFT、2LSB、2LV1、2OL9、2W9E、3HAF、3HAK、3HEQ、3HER、3HES、3HJ5、3HJX、3MD4、3MD5、3NHC、3NHD、3NVF、4DGI、4E1H、4E1I,%%s1E1G、1E1J、1E1P、1E1S、1E1U、1E1W、1FKC、1FO7、1H0L、1HJM、1HJN、1I4M、1OEH、1OEI、1QLX、1QLZ、1QM0、1QM1、1QM2、1QM3、2IV4、2IV5、2IV6、2K1D、2KUN、2LBG、2LEJ、2LFT、2LSB、2LV1、2M8T、2W9E、3HAF、3HAK、3HEQ、3HER、3HES、3HJ5、3HJX、3MD4、3MD5、3NHC、3NVF、4DGI、4E1H、4E1I、4KML、4N9O |
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| 識別號 |
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| 别名 | PRNP；, ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30, prion protein |
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| 外部ID | OMIM：176640 MGI：97769 HomoloGene：7904 GeneCards：PRNP |
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| 相關疾病 |
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| 傳染性海綿狀腦病、克雅二氏病、致死性家族失眠症、Gerstmann–Sträussler–Scheinker症候群、Huntington disease-like 1、spongiform encephalopathy with neuropsychiatric features、inherited Creutzfeldt–Jakob disease[1] |
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| RNA表达模式 |
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| 查阅更多表达数据 |
| 基因本體 |
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| 分子功能 | • chaperone binding
• transmembrane transporter binding
• microtubule binding
• ATP-dependent protein binding
• 金屬離子結合
• tubulin binding
• 血浆蛋白结合
• 相同蛋白质结合
• copper ion binding
• lamin binding
• amyloid-beta binding
• 蛋白酶結合
• glycosaminoglycan binding
• type 5 metabotropic glutamate receptor binding
• type 8 metabotropic glutamate receptor binding
• signaling receptor activity
• 大分子复合物结合
• cupric ion binding
• cuprous ion binding
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| 細胞組分 | • mitochondrial outer membrane
• 膜
• 線粒體
• integral component of membrane
• 細胞質
• 高尔基体
• 细胞膜
• cell surface
• 内质网
• 脂筏模型
• anchored component of membrane
• 外排體
• 细胞核
• extrinsic component of membrane
• 细胞质基质
• 突触后致密物质
• 包涵体
• 树突
• anchored component of external side of plasma membrane
• 核膜
• 細胞內膜結合細胞器
• postsynapse
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| 生物學過程 | • negative regulation of protein phosphorylation
• negative regulation of interferon-gamma production
• response to cadmium ion
• negative regulation of calcineurin-NFAT signaling cascade
• response to copper ion
• negative regulation of apoptotic process
• response to oxidative stress
• negative regulation of DNA-binding transcription factor activity
• negative regulation of T cell receptor signaling pathway
• regulation of protein localization
• negative regulation of activated T cell proliferation
• 学习和记忆
• cellular copper ion homeostasis
• cellular response to copper ion
• 細胞週期
• 代謝
• negative regulation of interleukin-17 production
• protein homooligomerization
• negative regulation of interleukin-2 production
• regulation of potassium ion transmembrane transport
• 长期记忆
• positive regulation of cell death
• negative regulation of protein processing
• protein destabilization
• activation of protein kinase activity
• calcium-mediated signaling using intracellular calcium source
• negative regulation of catalytic activity
• positive regulation of neuron apoptotic process
• regulation of peptidyl-tyrosine phosphorylation
• positive regulation of peptidyl-tyrosine phosphorylation
• positive regulation of protein tyrosine kinase activity
• positive regulation of protein targeting to membrane
• dendritic spine maintenance
• negative regulation of long-term synaptic potentiation
• regulation of glutamate receptor signaling pathway
• positive regulation of neuron death
• negative regulation of amyloid-beta formation
• regulation of intracellular calcium activated chloride channel activity
• negative regulation of dendritic spine maintenance
• negative regulation of amyloid precursor protein catabolic process
• positive regulation of protein localization to plasma membrane
• response to amyloid-beta
• cellular response to amyloid-beta
• regulation of calcium ion import across plasma membrane
• neuron projection maintenance
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| Sources:Amigo / QuickGO |
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| 直系同源 |
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| 物種 | 人類 | 小鼠 |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| mRNA序列 | NM_183079
NM_000311
NM_001080121
NM_001080122
NM_001080123
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NM_001271561 |
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| 蛋白序列 | NP_000302
NP_001073590
NP_001073591
NP_001073592
NP_001258490
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NP_898902
NP_000302.1
NP_001073590.1
NP_001073591.1
NP_001073592.1
NP_898902.1 |
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| 基因位置（UCSC） | Chr 20: 4.69 – 4.7 Mb | Chr 2: 131.75 – 131.78 Mb |
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| PubMed查找 | [4] | [5] |
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| 維基數據 |
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. PMID 3094007. doi:10.1073/pnas.83.19.7358 （英语）. 
