FOXP3 |
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已知的結構 |
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PDB | 直系同源搜索: PDBe RCSB |
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識別號 |
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别名 | FOXP3;, AIID, DIETER, IPEX, JM2, PIDX, XPID, forkhead box P3 |
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外部ID | OMIM:300292 MGI:1891436 HomoloGene:8516 GeneCards:FOXP3 |
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相關疾病 |
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IPEX症候群[1] |
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RNA表达模式 |
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查阅更多表达数据 |
基因本體 |
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分子功能 | • sequence-specific DNA binding • NF-kappaB binding • transcription corepressor activity • nucleic acid binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • 血浆蛋白结合 • histone deacetylase binding • DNA结合转录因子活性 • NFAT protein binding • histone acetyltransferase binding • 金屬離子結合 • DNA结合 • protein homodimerization activity • DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II cis-regulatory region sequence-specific DNA binding
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細胞組分 | • 细胞核 • 胞內 • 細胞質 • 核质 • 大分子复合体
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生物學過程 | • negative regulation of cell population proliferation • negative regulation of NF-kappaB transcription factor activity • B cell homeostasis • regulation of isotype switching to IgG isotypes • myeloid cell homeostasis • negative regulation of inflammatory response • positive regulation of interleukin-4 production • regulation of immunoglobulin production • regulation of transcription by RNA polymerase II • regulation of T cell anergy • negative regulation of interleukin-6 production • tolerance induction to self antigen • regulation of transcription, DNA-templated • negative regulation of DNA-binding transcription factor activity • positive regulation of T cell tolerance induction • negative regulation of immune response • negative regulation of interferon-gamma production • tolerance induction • regulatory T cell differentiation • positive regulation of transcription, DNA-templated • negative regulation of interleukin-2 production • positive regulation of histone acetylation • negative regulation of interleukin-5 production • negative regulation of chronic inflammatory response • CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation • positive regulation of transcription by RNA polymerase II • negative regulation of activated T cell proliferation • positive regulation of gene expression • negative regulation of interleukin-4 production • negative regulation of interleukin-10 production • 腫瘤壞死因子產生的負調控 • T cell homeostasis • negative regulation of CREB transcription factor activity • negative regulation of T-helper 17 cell differentiation • T细胞活化 • positive regulation of immature T cell proliferation in thymus • positive regulation of regulatory T cell differentiation • negative regulation of transcription by RNA polymerase II • positive regulation of peripheral T cell tolerance induction • positive regulation of transforming growth factor beta1 production • negative regulation of transcription, DNA-templated • negative regulation of lymphocyte proliferation • negative regulation of histone acetylation • negative regulation of interleukin-17 production • response to virus • negative regulation of histone deacetylation • CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment • positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation • negative regulation of T cell proliferation • 染色体重建 • cytokine production • negative regulation of T cell cytokine production • negative regulation of isotype switching to IgE isotypes • T cell receptor signaling pathway • positive regulation of T cell anergy • transcription, DNA-templated • T cell mediated immunity • negative regulation of gene expression • anatomical structure morphogenesis • regulation of Wnt signaling pathway • regulation of regulatory T cell differentiation
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | | |
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NM_001199347 NM_001199348 NM_054039 |
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蛋白序列 | | |
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NP_001186276 NP_001186277 NP_473380 |
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基因位置(UCSC) | Chr X: 49.25 – 49.27 Mb | Chr X: 7.44 – 7.46 Mb |
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PubMed查找 | [4] | [5] |
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維基數據 |
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