P53

TP53
Cấu trúc được biết đến PDB Tìm trên Human UniProt: PDBe RCSB Danh sách mã id PDB 4QO1, 1A1U, 1AIE, 1C26, 1DT7, 1GZH, 1H26, 1HS5, 1KZY, 1MA3, 1OLG, 1OLH, 1PES, 1PET, 1SAE, 1SAF, 1SAK, 1SAL, 1TSR, 1TUP, 1UOL, 1XQH, 1YC5, 1YCQ, 1YCR, 1YCS, 2AC0, 2ADY, 2AHI, 2ATA, 2B3G, 2BIM, 2BIN, 2BIO, 2BIP, 2BIQ, 2FEJ, 2FOJ, 2FOO, 2GS0, 2H1L, 2H2D, 2H2F, 2H4F, 2H4H, 2H4J, 2H59, 2J0Z, 2J10, 2J11, 2J1W, 2J1X, 2J1Y, 2J1Z, 2J20, 2J21, 2K8F, 2L14, 2LY4, 2MEJ, 2MWO, 2MWP, 2MZD, 2OCJ, 2PCX, 2RUK, 2VUK, 2WGX, 2X0U, 2X0V, 2X0W, 2XWR, 2YBG, 2YDR, 2Z5S, 2Z5T, 3D05, 3D06, 3D07, 3D08, 3D09, 3D0A, 3DAB, 3DAC, 3IGK, 3IGL, 3KMD, 3KZ8, 3LW1, 3OQ5, 3PDH, 3Q01, 3Q05, 3Q06, 3SAK, 3TG5, 3TS8, 3ZME, 4AGL, 4AGM, 4AGN, 4AGO, 4AGP, 4AGQ, 4BUZ, 4BV2, 4HFZ, 4HJE, 4IBQ, 4IBS, 4IBT, 4IBU, 4IBV, 4IBW, 4IBY, 4IBZ, 4IJT, 4KVP, 4LO9, 4LOE, 4LOF, 4MZI, 4MZR, 4X34, 4ZZJ, 5AOL, 5ABA, 5AOK, 2MWY, 5A7B, 5AOJ, 5AOI, 5ECG, 5AB9, 4FZ3, 4RP6, 4XR8, 5AOM, 4RP7, 5HOU, 5HP0, 5HPD, 5LGY, 5G4M, 5G4O, 5G4N, 5BUA
Mã định danh
Danh pháp	TP53, BCC7, LFS1, P53, TRP53, tumor protein p53, BMFS5, Genes, p53
ID ngoài	OMIM: 191170 HomoloGene: 460 GeneCards: TP53
Mẫu hình biểu hiện RNA Thêm nguồn tham khảo về sự biểu hiện
Bản thể gen Chức năng phân tử • protein N-terminus binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • protein self-association • core promoter sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • protein phosphatase binding • ATP binding • transcription factor binding • metal ion binding • protein phosphatase 2A binding • enzyme binding • zinc ion binding • chromatin binding • protease binding • damaged DNA binding • GO:0001948, GO:0016582 protein binding • histone acetyltransferase binding • copper ion binding • protein kinase binding • chaperone binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • receptor tyrosine kinase binding • p53 binding • identical protein binding • protein heterodimerization activity • ubiquitin protein ligase binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • TFIID-class transcription factor complex binding • mRNA 3'-UTR binding • histone deacetylase binding • disordered domain specific binding • promoter-specific chromatin binding • histone deacetylase regulator activity • protein homodimerization activity • MDM2/MDM4 family protein binding Thành phần tế bào • tế bào chất • Ty thể • nhân tế bào • nuclear body • transcription factor TFIID complex • nuclear matrix • replication fork • Hạch nhân • Mạng lưới nội chất • Chất nhân • mitochondrial matrix • PML body • cytosol • nội bào • transcription regulator complex • GO:0009327 protein-containing complex • site of double-strand break Quá trình sinh học • positive regulation of histone deacetylation • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • rhythmic process • replicative senescence • negative regulation of telomerase activity • oligodendrocyte apoptotic process • cellular response to DNA damage stimulus • intrinsic apoptotic signaling pathway • positive regulation of neuron apoptotic process • regulation of mitochondrial membrane permeability • positive regulation of reactive oxygen species metabolic process • cellular response to ionizing radiation • positive regulation of thymocyte apoptotic process • negative regulation of helicase activity • chu kỳ tế bào • Ras protein signal transduction • cell population proliferation • cellular response to hypoxia • negative regulation of cell population proliferation • nucleotide-excision repair • cellular response to glucose starvation • GO:0009373 regulation of transcription, DNA-templated • GO:1904576 response to antibiotic • transcription, DNA-templated • ER overload response • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of cell growth • intrinsic apoptotic signaling pathway by p53 class mediator • positive regulation of peptidyl-tyrosine phosphorylation • GO:0022415 viral process • response to gamma radiation • negative regulation of fibroblast proliferation • positive regulation of intrinsic apoptotic signaling pathway • biệt hóa tế bào • determination of adult lifespan • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress • cellular response to UV • DNA damage response, signal transduction by p53 class mediator • negative regulation of apoptotic process • protein tetramerization • oxidative stress-induced premature senescence • positive regulation of release of cytochrome c from mitochondria • circadian behavior • GO:0045996 negative regulation of transcription, DNA-templated • GO:0034613 protein localization • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • positive regulation of execution phase of apoptosis • multicellular organism development • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • GO:1901313 positive regulation of gene expression • mitotic G1 DNA damage checkpoint signaling • positive regulation of protein oligomerization • positive regulation of apoptotic process • entrainment of circadian clock by photoperiod • response to X-ray • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • base-excision repair • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • regulation of cell cycle G2/M phase transition • proteasome-mediated ubiquitin-dependent protein catabolic process • regulation of signal transduction by p53 class mediator • GO:0097285 Chết rụng tế bào • transcription by RNA polymerase II • positive regulation of protein export from nucleus • GO:0010703, GO:0010702 Sự chết theo chương trình của tế bào • regulation of apoptotic process • protein deubiquitination • phosphatidylinositol-mediated signaling • GO:1901227 negative regulation of transcription by RNA polymerase II • autophagy • mRNA transcription • cytokine-mediated signaling pathway • positive regulation of RNA polymerase II transcription preinitiation complex assembly • RNA polymerase II preinitiation complex assembly • protein homotetramerization • GO:0034622 protein-containing complex assembly • cellular response to gamma radiation • signal transduction by p53 class mediator • cellular response to actinomycin D • positive regulation of pri-miRNA transcription by RNA polymerase II • positive regulation of production of miRNAs involved in gene silencing by miRNA • in utero embryonic development • somitogenesis • release of cytochrome c from mitochondria • hematopoietic progenitor cell differentiation • T cell proliferation involved in immune response • B cell lineage commitment • T cell lineage commitment • response to ischemia • double-strand break repair • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • protein import into nucleus • GO:0001306 response to oxidative stress • transforming growth factor beta receptor signaling pathway • Hình thành phôi vị • negative regulation of neuroblast proliferation • central nervous system development • heart development • Nhịp điệu sinh học hàng ngày • negative regulation of DNA replication • rRNA transcription • response to UV • response to salt stress • embryo development ending in birth or egg hatching • negative regulation of gene expression • positive regulation of cardiac muscle cell apoptotic process • cerebellum development • negative regulation of transforming growth factor beta receptor signaling pathway • T cell differentiation in thymus • regulation of tissue remodeling • multicellular organism growth • positive regulation of mitochondrial membrane permeability • positive regulation of transcription from RNA polymerase II promoter in response to stress • regulation of cell population proliferation • mitochondrial DNA repair • regulation of DNA damage response, signal transduction by p53 class mediator • regulation of neuron apoptotic process • negative regulation of proteolysis • negative regulation of mitotic cell cycle • bone marrow development • embryonic organ development • protein stabilization • GO:0051312, GO:0007083 chromosome organization • neuron apoptotic process • regulation of cell cycle • hematopoietic stem cell differentiation • interferon-gamma-mediated signaling pathway • cardiac septum morphogenesis • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia • positive regulation of programmed necrotic cell death • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • regulation of thymocyte apoptotic process • GO:0060554, GO:0060555 necroptosis • cellular response to UV-C • negative regulation of mitophagy • regulation of mitochondrial membrane permeability involved in apoptotic process • regulation of intrinsic apoptotic signaling pathway by p53 class mediator • negative regulation of production of miRNAs involved in gene silencing by miRNA • negative regulation of glucose catabolic process to lactate via pyruvate • intrinsic apoptotic signaling pathway in response to hypoxia • regulation of fibroblast apoptotic process • negative regulation of reactive oxygen species metabolic process • regulation of cellular senescence Nguồn: Amigo / QuickGO
Gen cùng nguồn
Loài	Người	Chuột
Entrez	7157	n/a
Ensembl	ENSG00000141510	n/a
UniProt	P04637	n/a
RefSeq (mRNA)	NM_001276761 NM_000546 NM_001126112 NM_001126113 NM_001126114 NM_001126115 NM_001126116 NM_001126117 NM_001126118 NM_001276695 NM_001276696 NM_001276697 NM_001276698 NM_001276699 NM_001276760	n/a
RefSeq (protein)	NP_000537 NP_001119584 NP_001119585 NP_001119586 NP_001119587 NP_001119588 NP_001119589 NP_001119590 NP_001263624 NP_001263625 NP_001263626 NP_001263627 NP_001263628 NP_001263689 NP_001263690	n/a
Vị trí gen (UCSC)	n/a	n/a
PubMed	[1]	n/a
Wikidata
Xem/Sửa Người

Tumor protein p53, hay còn gọi là p53 là một protein quan trọng nằm trong điều hòa chu kỳ tế bào - gọi là gen áp chế khối u p53. Khi có tổn thương ở DNA, p53 làm ngừng chu kỳ tế bào cho đến khi DNA bị tổn thương được sửa chữa hoặc p53 có thể làm sự chết rụng tế bào (tiếng Anh apoptosis) nếu không còn khả năng sửa chữa DNA.

Rb là gen có chức năng ngăn cản diễn tiến chu kỳ tế bào bằng cách gắn kết với E2F1 và ngăn cản sự sao chép các gen cần thiết cho tế bào vào pha S. Sở dĩ p53 ngăn cản được chu trình tế bào vì nó hoạt hóa quá trình phiên mã tạo ra CKI, P21 để luân phiên ức chế sự hoạt hóa của CDK. Một khi CDK bị hoạt hóa nó sẽ phosphoryl hóa Rb và làm mất tác dụng của Rb.

Những đột biến mất chức năng p53 làm tăng tính bất ổn định di truyền và làm giảm chết tế bào theo lập trình. Người ta phát hiện thấy trên 50% người mắc các bệnh về ung thư (như ung thư vú, ung thư đại tràng, ung thư phổi, ung thư gan...) đều có những điểm khác biệt trên gene mã hoá p53 so với người bình thường.

Hình ảnh

Tham khảo

Nguyễn ánh

• Mutations of the p53 Gene as a Prognostic Factor in Aggressive B-Cell Lymphoma - NEJM
• Medical Progress: Clinical Implications of the p53 Tumor-Suppressor Gene - NEJM
• Cancer Therapy Meets p53 - NEJM

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