Sodium ferulate

Sodium ferulate
Names
Preferred IUPAC name
Sodium (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
Identifiers
CAS Number
  • 24276-84-4 checkY
3D model (JSmol)
  • Interactive image
ChEBI
  • CHEBI:114954 ☒N
ChemSpider
  • 4479130 checkY
PubChem CID
  • 5321361
UNII
  • OIS7F1IRQK checkY
CompTox Dashboard (EPA)
  • DTXSID601034731 DTXSID80894080, DTXSID601034731 Edit this at Wikidata
InChI
  • InChI=1S/C10H10O4.Na/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13;/h2-6,11H,1H3,(H,12,13);/q;+1/p-1/b5-3+; checkY
    Key: NCTHNHPAQAVBEB-WGCWOXMQSA-M checkY
  • InChI=1/C10H10O4.Na/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13;/h2-6,11H,1H3,(H,12,13);/q;+1/p-1/b5-3+;
    Key: NCTHNHPAQAVBEB-OLHRVHTCBT
  • [Na+].[O-]C(=O)\C=C\c1cc(OC)c(O)cc1
Properties
Chemical formula
 C10H9NaO4
Molar mass 216.17 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound

Sodium ferulate, the sodium salt of ferulic acid, is a compound used in traditional Chinese medicine thought to be useful for treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis, although there is no high-quality clinical evidence for such effects. It is found in the root of Angelica sinensis. As of 2005, it was under preliminary clinical research in China.[1] Ferulic acid can also be extracted from the root of the Chinese herb Ligusticum chuanxiong.[2]

Kraft Foods patented the use of sodium ferulate to mask the aftertaste of the artificial sweetener acesulfame potassium.[3]

References

  1. ^ Wang, B. H.; Ou-Yang, J. P. (2005). "Pharmacological Actions of Sodium Ferulate in Cardiovascular System". Cardiovascular Drug Reviews. 23 (2): 161–172. doi:10.1111/j.1527-3466.2005.tb00163.x. PMID 16007232.
  2. ^ Wang, W.; Sun, Y. (2008). "Ultrasonic Extraction of Ferulic Acid from Ligusticum chuanxiong". Journal of the Chinese Institute of Chemical Engineers. 39 (6): 653–656. doi:10.1016/j.jcice.2008.05.012.
  3. ^ US patent 5336513, Riemer, J. A., "Bitterness Inhibitors", issued 1994-08-09, assigned to Kraft General Foods  (expired in 2006 due to non-payment of fees)
  • v
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Receptor
(ligands)
P0 (adenine)
P1
(adenosine)
P2
(nucleotide)
P2X
(ATPTooltip Adenosine triphosphate)
P2Y
Transporter
(blockers)
CNTsTooltip Concentrative nucleoside transporters
ENTsTooltip Equilibrative nucleoside transporters
PMATTooltip Plasma membrane monoamine transporter
Enzyme
(inhibitors)
XOTooltip Xanthine oxidase
Others
Others
See also: Receptor/signaling modulators