Propoxur

Propoxur

Names
Preferred IUPAC name 2-[(Propan-2-yl)oxy]phenyl methylcarbamate
Identifiers
CAS Number	114-26-1 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:34938 N
ChEMBL	ChEMBL446060 N
ChemSpider	4775 N
ECHA InfoCard	100.003.676
KEGG	C14334 Y
PubChem CID	4944
UNII	BFH029TL73 Y
CompTox Dashboard (EPA)	DTXSID7021948
InChI InChI=1S/C11H15NO3/c1-8(2)14-9-6-4-5-7-10(9)15-11(13)12-3/h4-8H,1-3H3,(H,12,13) Key: ISRUGXGCCGIOQO-UHFFFAOYSA-N
SMILES CC(C)Oc1ccccc1OC(=O)NC
Properties
Chemical formula	C11H15NO3
Molar mass	209.245 g·mol−1
Appearance	White to tan crystalline powder[1]
Odor	faint, characteristic[1]
Melting point	86 to 92 °C; 187 to 197 °F; 359 to 365 K
Boiling point	decomposes[1]
Solubility in water	0.2% (20°C)[1]
Vapor pressure	0.0000937 mmHg (20 °C)[1]
Pharmacology
ATCvet code	QP53AE02 (WHO)
Hazards
Flash point	> 149 °C; 300 °F; 422 K
NIOSH (US health exposure limits):
PEL (Permissible)	none[1]
REL (Recommended)	TWA 0.5 mg/m3[1]
IDLH (Immediate danger)	N.D.[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Propoxur (Baygon) is a carbamate non-systemic insecticide, produced from catechol,^[2] and was introduced in 1959. It has a fast knockdown and long residual effect, and is used against turf, forestry, and household pests and fleas. It is also used in pest control for domestic animals, Anopheles mosquitoes, ants, gypsy moths, and other agricultural pests.^[3][4] It can also be used as a molluscicide.^[4][5][6]

Several U.S. states have petitioned the Environmental Protection Agency (EPA) to use propoxur against bedbug infestations, but the EPA has been reluctant to approve indoor use because of its potential toxicity to children after chronic exposure.^[7]

Action

Carbamate insecticides kill insects by irreversibly inactivating the enzyme acetylcholinesterase, thus it is a Cholinesterase inhibitor.

Environmental effects

Propoxur rapidly breaks down in alkaline solution.^[8] Propoxur is highly toxic to many bird species, although its toxicity varies by the species, and it is highly toxic to honeybees.^[6] It is moderately to slightly toxic to fish and other aquatic species.

References