MPP5

Protein-coding gene in the species Homo sapiens

PALS1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1Y76, 3UIT, 4UU5, 4UU6, 4WSI

Identifiers

Aliases

PALS1, membrane palmitoylated protein 5, protein associated with LIN7 1, MAGUK p55 family member, MPP5, protein associated with LIN7 1, MAGUK family member

External IDs

OMIM: 606958; MGI: 1927339; HomoloGene: 9512; GeneCards: PALS1; OMA:PALS1 - orthologs

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q23.3	Start	67,240,713 bp^[1]
Band	14q23.3	End	67,336,061 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 C3	Start	78,795,681 bp^[2]
Band	12\|12 C3	End	78,887,488 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

jejunal mucosa

ventricular zone

germinal epithelium

retinal pigment epithelium

corpus callosum

inferior ganglion of vagus nerve

biceps brachii

Skeletal muscle tissue of biceps brachii

amniotic fluid

corpus epididymis

Top expressed in

zygote

tail of embryo

spermatid

otic placode

genital tubercle

saccule

secondary oocyte

otic vesicle

left lung lobe

epithelium of small intestine

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein domain specific binding protein binding
Cellular component	cytoplasm membrane bicellular tight junction myelin sheath adaxonal region Schmidt-Lanterman incisure cell junction lateral loop extracellular exosome endomembrane system plasma membrane protein-containing complex
Biological process	establishment of epithelial cell polarity peripheral nervous system myelin maintenance protein localization to myelin sheath abaxonal region myelin assembly bicellular tight junction assembly plasma membrane organization morphogenesis of an epithelial sheet protein localization to plasma membrane
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


64398


56217

Ensembl


ENSG00000072415


ENSMUSG00000021112

UniProt


Q8N3R9


Q9JLB2

RefSeq (mRNA)


NM_001256550 NM_022474


NM_019579

RefSeq (protein)


NP_001243479 NP_071919


NP_062525

Location (UCSC)

Chr 14: 67.24 – 67.34 Mb

Chr 12: 78.8 – 78.89 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

MAGUK p55 subfamily member 5 is a protein that in humans is encoded by the MPP5 gene.^[5]^[6] Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains (Tseng et al., 2001). MPP5 is a member of the p55-like MAGUK subfamily.[supplied by OMIM]^[6]

Interactions

MPP5 has been shown to interact with INADL and FAM71D.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000072415 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021112 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B (Apr 2002). "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost". J Cell Biol. 157 (1): 161–72. doi:10.1083/jcb.200109010. PMC 2173254. PMID 11927608.
^ ^a ^b "Entrez Gene: MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)".

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Kamberov E, Makarova O, Roh M, et al. (2000). "Molecular cloning and characterization of Pals, proteins associated with mLin-7". J. Biol. Chem. 275 (15): 11425–31. doi:10.1074/jbc.275.15.11425. PMID 10753959.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Tseng TC, Marfatia SM, Bryant PJ, et al. (2001). "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain". Biochim. Biophys. Acta. 1518 (3): 249–59. doi:10.1016/s0167-4781(01)00191-9. PMID 11311936.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Makarova O, Roh MH, Liu CJ, et al. (2003). "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)". Gene. 302 (1–2): 21–9. doi:10.1016/S0378111902010843. PMID 12527193.
Hurd TW, Gao L, Roh MH, et al. (2003). "Direct interaction of two polarity complexes implicated in epithelial tight junction assembly". Nat. Cell Biol. 5 (2): 137–42. doi:10.1038/ncb923. PMID 12545177. S2CID 25212419.
Roh MH, Fan S, Liu CJ, Margolis B (2004). "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells". J. Cell Sci. 116 (Pt 14): 2895–906. doi:10.1242/jcs.00500. PMID 12771187. S2CID 4482921.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Penkert RR, DiVittorio HM, Prehoda KE (2004). "Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex". Nat. Struct. Mol. Biol. 11 (11): 1122–7. doi:10.1038/nsmb839. PMC 2140275. PMID 15475968.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Stöhr H, Molday LL, Molday RS, et al. (2005). "Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina" (PDF). J. Comp. Neurol. 481 (1): 31–41. doi:10.1002/cne.20367. PMID 15558731. S2CID 19904556.
Feng W, Long JF, Zhang M (2005). "A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins". Proc. Natl. Acad. Sci. U.S.A. 102 (19): 6861–6. Bibcode:2005PNAS..102.6861F. doi:10.1073/pnas.0409346102. PMC 1100767. PMID 15863617.
Kantardzhieva A, Gosens I, Alexeeva S, et al. (2005). "MPP5 recruits MPP4 to the CRB1 complex in photoreceptors". Invest. Ophthalmol. Vis. Sci. 46 (6): 2192–201. doi:10.1167/iovs.04-1417. PMID 15914641.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.