HAUS3

Protein-coding gene in the species Homo sapiens
HAUS3
Identifiers
AliasesHAUS3, C4orf15, IT1, dgt3, HAUS augmin like complex subunit 3
External IDsOMIM: 613430; MGI: 2387633; HomoloGene: 75209; GeneCards: HAUS3; OMA:HAUS3 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for HAUS3
Genomic location for HAUS3
Band4p16.3Start2,078,998 bp[1]
End2,242,276 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for HAUS3
Genomic location for HAUS3
Band5 B2|5 17.84 cMStart34,311,224 bp[2]
End34,326,871 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • gonad

  • Achilles tendon

  • ventricular zone

  • oral cavity

  • visceral pleura

  • parietal pleura

  • ganglionic eminence

  • bone marrow

  • skin of thigh
Top expressed in
  • primary oocyte

  • secondary oocyte

  • zygote

  • primitive streak

  • maxillary prominence

  • mandibular prominence

  • abdominal wall

  • thymus

  • epiblast

  • tail of embryo
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • molecular function
Cellular component
  • microtubule cytoskeleton
  • cytoplasm
  • microtubule organizing center
  • centrosome
  • microtubule
  • HAUS complex
  • cytoskeleton
  • mitochondrion
  • nucleoplasm
  • cytosol
  • spindle
  • intercellular bridge
  • mitotic spindle
Biological process
  • spindle assembly
  • cell cycle
  • cell division
  • G2/M transition of mitotic cell cycle
  • ciliary basal body-plasma membrane docking
  • centrosome cycle
  • regulation of G2/M transition of mitotic cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79441

231123

Ensembl

ENSG00000214367

ENSMUSG00000079555

UniProt

Q68CZ6

Q8QZX2

RefSeq (mRNA)

NM_024511
NM_001303143

NM_146159

RefSeq (protein)

NP_001290072
NP_078787

NP_666271

Location (UCSC)Chr 4: 2.08 – 2.24 MbChr 5: 34.31 – 34.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

HAUS augmin-like complex subunit 3 is a protein that in humans is encoded by the HAUS3 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000214367 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079555 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: HAUS augmin-like complex".
  6. ^ Lawo S, Bashkurov M, Mullin M, Ferreria MG, Kittler R, Habermann B, Tagliaferro A, Poser I, Hutchins JR, Hegemann B, Pinchev D, Buchholz F, Peters JM, Hyman AA, Gingras AC, Pelletier L (May 2009). "HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity". Curr. Biol. 19 (10): 816–26. Bibcode:2009CBio...19..816L. doi:10.1016/j.cub.2009.04.033. PMID 19427217. S2CID 2893122.

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Uehara R, Nozawa RS, Tomioka A, et al. (2009). "The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells". Proc. Natl. Acad. Sci. U.S.A. 106 (17): 6998–7003. Bibcode:2009PNAS..106.6998U. doi:10.1073/pnas.0901587106. PMC 2668966. PMID 19369198.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.


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