CHST12

Protein-coding gene in the species Homo sapiens
CHST12
Identifiers
AliasesCHST12, C4S-2, C4ST-2, C4ST2, carbohydrate (chondroitin 4) sulfotransferase 12, carbohydrate sulfotransferase 12
External IDsOMIM: 610129; MGI: 1929064; HomoloGene: 69258; GeneCards: CHST12; OMA:CHST12 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for CHST12
Genomic location for CHST12
Band7p22.3Start2,403,588 bp[1]
End2,448,484 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for CHST12
Genomic location for CHST12
Band5|5 G2Start140,491,305 bp[2]
End140,511,479 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • secondary oocyte

  • cerebellar vermis

  • granulocyte

  • synovial joint

  • stromal cell of endometrium

  • apex of heart

  • spleen

  • blood

  • bone marrow cells
Top expressed in
  • granulocyte

  • decidua

  • interventricular septum

  • ankle

  • calvaria

  • belly cord

  • lumbar spinal ganglion

  • stroma of bone marrow

  • white adipose tissue

  • yolk sac
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • sulfotransferase activity
  • 3'-phosphoadenosine 5'-phosphosulfate binding
  • chondroitin 4-sulfotransferase activity
Cellular component
  • integral component of membrane
  • integral component of Golgi membrane
  • Golgi membrane
  • Golgi apparatus
  • membrane
Biological process
  • chondroitin sulfate biosynthetic process
  • dermatan sulfate biosynthetic process
  • carbohydrate biosynthetic process
  • carbohydrate metabolic process
  • proteoglycan biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55501

59031

Ensembl

ENSG00000136213

ENSMUSG00000036599

UniProt

Q9NRB3

Q99LL3

RefSeq (mRNA)

NM_001243794
NM_001243795
NM_018641

NM_021528

RefSeq (protein)

NP_001230723
NP_001230724
NP_061111

NP_067503

Location (UCSC)Chr 7: 2.4 – 2.45 MbChr 5: 140.49 – 140.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carbohydrate sulfotransferase 12 is an enzyme that in humans is encoded by the CHST12 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136213 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036599 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hiraoka N, Nakagawa H, Ong E, Akama TO, Fukuda MN, Fukuda M (Aug 2000). "Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family". J Biol Chem. 275 (26): 20188–96. doi:10.1074/jbc.M002443200. PMID 10781601.
  6. ^ "Entrez Gene: CHST12 carbohydrate (chondroitin 4) sulfotransferase 12".

External links

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Mikami T, Mizumoto S, Kago N, et al. (2003). "Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis". J. Biol. Chem. 278 (38): 36115–27. doi:10.1074/jbc.M306044200. PMID 12847091.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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