Bertilimumab
Chemical compound
N
Y (what is this?) (verify) Bertilimumab is a human monoclonal antibody that binds to eotaxin-1, an important regulator of overall eosinophil function.
It was discovered by Cambridge Antibody Technology using their phage display technology.[1] Named CAT-213 during early discovery and development by CAT, it was to be used to treat severe allergic disorders.[2]
In January 2007, CAT licensed the drug for treatment of allergy disorders to iCo Therapeutics Inc.[3] iCo Therapeutics Inc. is a Vancouver-based reprofiling company focused on redosing or reformulating drugs with clinical history for new or expanded indications - a so-called 'search and development company'.[4]
iCo Therapeutics Inc. renamed the drug from CAT-213 to iCo-008 and, at that stage, planned to initiate a Phase II clinical trial in patients with vernal keratoconjunctivitis.[5]
In March 2008, iCo announced iCo-008 had been in 126 patients in Phase I and II clinical trials. The drug substance had been manufactured by Lonza, in its cGMP facilities in Slough, UK. Subsequently, iCo moved the drug substance to a fill-finish site for the final stage of manufacturing. iCo reported that the iCo-008 drug product was within specifications and contained a high antibody yield.[6]
References
- ^ Main S, Handy R, Wilton J, Smith S, Williams L, Fou LD, et al. (December 2006). "A potent human anti-eotaxin1 antibody, CAT-213: isolation by phage display and in vitro and in vivo efficacy". The Journal of Pharmacology and Experimental Therapeutics. 319 (3): 1395–404. doi:10.1124/jpet.106.110734. PMID 16973884. S2CID 20865759.
- ^ Ding C, Li J, Zhang X (November 2004). "Bertilimumab Cambridge Antibody Technology Group". Current Opinion in Investigational Drugs. 5 (11): 1213–8. PMID 15573873.
- ^ "Cambridge Antibody Tech. licenses monoclonal antibody for treatment of allergy disorders to iCo". iCo Therapeutics. Archived from the original on 2009-05-01. Retrieved 2009-08-01.
- ^ "iCo Therapeutics". iCo Therapeutics. Archived from the original on 2009-07-28. Retrieved 2009-08-01.
- ^ "iCo008". iCo Therapeutics. Archived from the original on 2009-07-28. Retrieved 2009-08-01.
- ^ "iCo Therapeutics Provides iCo-008 Phase II Clinical Update". iCo Therapeutics. Archived from the original on 2009-05-01. Retrieved 2009-08-01.
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