BET1L

Protein-coding gene in the species Homo sapiens
BET1L
Identifiers
AliasesBET1L, BET1L1, GOLIM3, GS15, HSPC197, Bet1 golgi vesicular membrane trafficking protein like
External IDsOMIM: 615417; MGI: 1913128; HomoloGene: 10293; GeneCards: BET1L; OMA:BET1L - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for BET1L
Genomic location for BET1L
Band11p15.5Start167,784 bp[1]
End207,399 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for BET1L
Genomic location for BET1L
Band7|7 F4Start140,433,307 bp[2]
End140,437,490 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • anterior pituitary

  • left ovary

  • right coronary artery

  • Descending thoracic aorta

  • body of stomach

  • gastric mucosa

  • canal of the cervix

  • ascending aorta

  • stromal cell of endometrium
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • molar

  • parotid gland

  • granulocyte

  • seminal vesicula

  • calvaria

  • spermatocyte

  • motor neuron

  • crypt of lieberkuhn of small intestine

  • decidua
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • SNAP receptor activity
Cellular component
  • integral component of membrane
  • Golgi membrane
  • endosome
  • Golgi apparatus
  • SNARE complex
  • membrane
  • cytosol
  • Golgi trans cisterna
  • Golgi stack
  • integral component of Golgi membrane
Biological process
  • protein transport
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • retrograde transport, endosome to Golgi
  • regulation of retrograde vesicle-mediated transport, Golgi to ER
  • membrane fusion
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51272

54399

Ensembl

ENSG00000177951

ENSMUSG00000025484

UniProt

Q9NYM9

O35153

RefSeq (mRNA)

NM_016526
NM_001098787
NM_016465

NM_018742

RefSeq (protein)

NP_001092257
NP_057610

NP_061212

Location (UCSC)Chr 11: 0.17 – 0.21 MbChr 7: 140.43 – 140.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

BET1-like protein is a protein that in humans is encoded by the BET1L gene.[5][6][7]

Interactions

BET1L has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177951 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025484 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Xu Y, Wong SH, Zhang T, Subramaniam VN, Hong W (Sep 1997). "GS15, a 15-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) homologous to rbet1". J Biol Chem. 272 (32): 20162–6. doi:10.1074/jbc.272.32.20162. PMID 9242691.
  6. ^ Oka T, Ungar D, Hughson FM, Krieger M (Apr 2004). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins". Mol Biol Cell. 15 (5): 2423–35. doi:10.1091/mbc.E03-09-0699. PMC 404034. PMID 15004235.
  7. ^ "Entrez Gene: BET1L blocked early in transport 1 homolog (S. cerevisiae)-like".
  8. ^ a b c Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
  9. ^ a b c Xu Y, Martin S, James DE, Hong W (Oct 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Mol. Biol. Cell. 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC 129961. PMID 12388752.

External links

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
  • Zhang T, Hong W (2001). "Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport". J. Biol. Chem. 276 (29): 27480–7. doi:10.1074/jbc.M102786200. PMID 11323436.
  • Shorter J, Beard MB, Seemann J, et al. (2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
  • Xu Y, Martin S, James DE, Hong W (2003). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Mol. Biol. Cell. 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC 129961. PMID 12388752.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Tai G, Lu L, Wang TL, et al. (2005). "Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network". Mol. Biol. Cell. 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMC 515336. PMID 15215310.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.


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