Protein-coding gene in the species Homo sapiens
| DNAJC6 |
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| Identifiers |
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| Aliases | DNAJC6, DJC6, PARK19, Auxilin, DnaJ heat shock protein family (Hsp40) member C6 |
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| External IDs | OMIM: 608375; MGI: 1919935; HomoloGene: 8865; GeneCards: DNAJC6; OMA:DNAJC6 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 1 (human)[1] |
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| | Band | 1p31.3 | Start | 65,248,219 bp[1] |
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| End | 65,415,871 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 4 (mouse)[2] |
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| | Band | 4|4 C6 | Start | 101,353,828 bp[2] |
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| End | 101,499,996 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - endothelial cell
- Brodmann area 23
- orbitofrontal cortex
- middle temporal gyrus
- pons
- inferior olivary nucleus
- Brodmann area 46
- superior vestibular nucleus
- Region I of hippocampus proper
- postcentral gyrus
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| | Top expressed in | - medial dorsal nucleus
- dorsomedial hypothalamic nucleus
- ventral tegmental area
- pontine nuclei
- medial geniculate nucleus
- paraventricular nucleus of hypothalamus
- lateral geniculate nucleus
- piriform cortex
- primary motor cortex
- subiculum
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - protein tyrosine phosphatase activity
- SH3 domain binding
- phosphoprotein phosphatase activity
- hydrolase activity
- clathrin binding
| | Cellular component | - cytosol
- synapse
- vesicle
- postsynaptic density
- cytoplasm
- intracellular membrane-bounded organelle
- presynapse
| | Biological process | - peptidyl-tyrosine dephosphorylation
- regulation of clathrin-dependent endocytosis
- protein dephosphorylation
- clathrin coat disassembly
- receptor-mediated endocytosis
- membrane organization
- synaptic vesicle uncoating
- clathrin-dependent endocytosis
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_001256864
NM_001256865
NM_014787 |
| NM_001164583
NM_001164584
NM_001164585
NM_198412
NM_001355179
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NM_001355180 |
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| RefSeq (protein) | |
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NP_001243793
NP_001243794
NP_055602 |
| NP_001158055
NP_001158056
NP_001158057
NP_940804
NP_001342108
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NP_001342109 |
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| Location (UCSC) | Chr 1: 65.25 – 65.42 Mb | Chr 4: 101.35 – 101.5 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene.[5][6][7]
Function
DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc-finger domain (Ohtsuka and Hata, 2000).[7]
Structure
The protein tyrosine phosphatase domain and C2 domain pair of auxilin, located near the N-terminus of the polypeptide, constitute a superdomain, a tandem arrangement of two or more nominally unrelated domains that form a single heritable unit.[8] The phosphatase domain belongs to the auxilin subfamily of lipid phosphatases and is predicted to be catalytically inactive.[9][10]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000116675 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028528 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (October 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
- ^ Ohtsuka K, Hata M (April 2000). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 2024-03-12). PMC 312896. PMID 11147971.
{{cite journal}}: CS1 maint: DOI inactive as of March 2024 (link) - ^ a b "Entrez Gene: DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6".
- ^ Haynie DT, Xue B (May 2015). "Superdomains in the protein structure hierarchy: The case of PTP-C2". Protein Science. 24 (5): 874–82. doi:10.1002/pro.2664. PMC 4420535. PMID 25694109.
- ^ "Phosphatase Subfamily Auxilin - PhosphataseWiki". phosphatome.net.
- ^ Chen MJ, Dixon JE, Manning G (April 2017). "Genomics and evolution of protein phosphatases". Science Signaling. 10 (474): eaag1796. doi:10.1126/scisignal.aag1796. PMID 28400531. S2CID 41041971.
External links
Further reading
- Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Scheele U, Alves J, Frank R, Duwel M, Kalthoff C, Ungewickell E (July 2003). "Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin". The Journal of Biological Chemistry. 278 (28): 25357–68. doi:10.1074/jbc.M303738200. PMID 12732633.
- Scheele U, Kalthoff C, Ungewickell E (September 2001). "Multiple interactions of auxilin 1 with clathrin and the AP-2 adaptor complex". The Journal of Biological Chemistry. 276 (39): 36131–8. doi:10.1074/jbc.M106511200. PMID 11470803.
- Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
1n4c: NMR Structure of the J-Domain and Clathrin Substrate Binding Domain of Bovine Auxilin
1nz6: Crystal Structure of Auxilin J-Domain
