Benazepril

Medication used to treat high blood pressure and heart failure

  • US DailyMed: Benazepril
Routes of
administrationBy mouthATC code
  • C09AA07 (WHO)
Legal statusLegal status
  • US: ℞-only[1]
  • In general: ℞ (Prescription only)
Pharmacokinetic dataProtein binding96.7%MetabolismLiver glucuronidationElimination half-life10-11 hoursExcretionKidney and bile ductIdentifiers
  • 2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid
CAS Number
  • 86541-75-5 checkY
PubChem CID
  • 5362124
IUPHAR/BPS
  • 6374
DrugBank
  • DB00542 checkY
ChemSpider
  • 4514935 checkY
UNII
  • UDM7Q7QWP8
KEGG
  • D07499
  • D00620
ChEBI
  • CHEBI:3011 checkY
ChEMBL
  • ChEMBL838 checkY
CompTox Dashboard (EPA)
  • DTXSID5022645 Edit this at Wikidata
Chemical and physical dataFormulaC24H28N2O5Molar mass424.497 g·mol−13D model (JSmol)
  • Interactive image
  • O=C(OCC)[C@@H](N[C@@H]2C(=O)N(c1ccccc1CC2)CC(=O)O)CCc3ccccc3
  • InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1 checkY
  • Key:XPCFTKFZXHTYIP-PMACEKPBSA-N checkY
  (verify)

Benazepril, sold under the brand name Lotensin among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease.[2] It is a reasonable initial treatment for high blood pressure.[2] It is taken by mouth.[2] Versions are available as the combinations benazepril/hydrochlorothiazide and benazepril/amlodipine.[2]

Common side effects include feeling tired, dizziness, cough, and light-headedness with standing.[2] Serious side effects may include kidney problems, low blood pressure, high blood potassium, and angioedema.[2] Use in pregnancy may harm the baby, while use when breastfeeding may be safe.[3] It is an ACE inhibitor and works by decreasing renin-angiotensin-aldosterone system activity.[2]

Benazepril was patented in 1981 and came into medical use in 1990. It is available as a generic medication.[2] In 2021, it was the 147th most commonly prescribed medication in the United States, with more than 3 million prescriptions.[4][5]

Medical uses

Lotensin is indicated for the treatment of hypertension, to lower blood pressure.[1][2]

Side effects

The most common side effects patients experience are a headache or a chronic cough. The chronic cough develops in about 20% of people treated.[6]

Contraindications

Benazepril can harm the fetus.[7]

Dosage forms

It is also available in combination with hydrochlorothiazide, under the brand name Lotensin HCT, and with amlodipine (Lotrel).

Veterinary uses

Under the brand names Fortekor (Novartis) and VetACE (Jurox Animal Health),[citation needed] benazepril is used to treat congestive heart failure in dogs[8][9] and chronic kidney failure in cats and dogs.[10]

References

  1. ^ a b "Lotensin- benazepril hydrochloride tablet". DailyMed. 21 January 2019. Retrieved 11 February 2024.
  2. ^ a b c d e f g h i "Benazepril Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
  3. ^ "Benazepril Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
  4. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  5. ^ "Benazepril - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
  6. ^ Dykewicz MS (April 2004). "Cough and Angioedema From Angiotensin-Converting Enzyme Inhibitors: New Insights Into Mechanisms and Management". Medscape. Retrieved 2 April 2014.
  7. ^ "Lotensin package insert" (PDF). U.S. Food and Drug Administration (FDA). 2011. Retrieved 9 December 2020.
  8. ^ King JN, Mauron C, Kaiser G (December 1995). "Pharmacokinetics of the active metabolite of benazepril, benazeprilat, and inhibition of plasma angiotensin-converting enzyme activity after single and repeated administrations to dogs". American Journal of Veterinary Research. 56 (12): 1620–1628. PMID 8599524.
  9. ^ O'Grady MR, O'Sullivan ML, Minors SL, Horne R (2009). "Efficacy of benazepril hydrochloride to delay the progression of occult dilated cardiomyopathy in Doberman Pinschers". Journal of Veterinary Internal Medicine. 23 (5): 977–983. doi:10.1111/j.1939-1676.2009.0346.x. PMID 19572914.
  10. ^ "Fortekor Flavor Tabs (5 mg) (Canada) for Animal Use". Drugs.com. Retrieved 9 December 2020.
  • v
  • t
  • e
ACE inhibitors
("-pril")AIIRAs
("-sartan")Renin inhibitors
("-kiren")Dual ACE/NEP inhibitors
Neprilysin inhibitors
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  • e
ATRTooltip Angiotensin receptor
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